The tolerance of hyaluronic acid is exceptionally good, but since every intervention in the human body carries risks, the possible side effects range from common reactions such as redness and swelling to very rare complications such as the occlusion of a blood vessel or an allergic reaction. Therefore, treatment with hyaluronan filler should always be carried out by an experienced physician who is aware of possible risks and side effects and can react to them if necessary.

Frequent side effects are pain due to the insertion of the needle, feelings of tension, itching, swelling of the lips (after treatment of the lips with hyaluron) and bruising, which disappears within a few days.

Rarely, there are circulatory problems, infections at the injection site and a displacement and nodulation of the injected substance.

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